Switching Machines: Volume 1: Combinational Systems Introduction to Sequential Systems

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Emphasis is given to Swarm Intelligence, Distributed control. Total grant 1. Emphasis is given to Swarm Intelligence, Robotics. A CTI project of two years concerning cutting sequence optimization. Emphasis is given to Robust OptimizationPlanning. Interface between academic institutions and industrial partners to introduce and promote innovation. CEO of Archimede sas. Current Research Topics:. Artificial Intelligence with focus on meta-heuristics algorithms, machine learning and swarm intelligence.

Operational Research and IT with focus on scheduling, vehicle routing and robust optimization. Management Experiences:. He has been awarded more than Supervisor of 14 PhD theses four in progress. He has published papers including peer review journals 76 international conferences book chapters 18 and book 1. His hnumber is His paper on Ant Colony Optimization Artificial Life received more than 3, citations and it is the most cited paper ever published by the Artificial Life journal. Swiss Patent. Experiments were performed using a minimum of three biologically distinct replicates.

Sample sizes were not based on power analyses as the efficiency of HIV-1 elimination was not known nor could it be projected. The sequencing data reported in this paper are included in the Source Data file. The source data underlying Figs.

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All other relevant data supporting the key findings of this study are available within the article and its supplementary files or from the corresponding authors upon reasonable request. Chun, T. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.

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USA 94 , — Lorenzo-Redondo, R. Persistent HIV-1 replication maintains the tissue reservoir during therapy. Nature , 51—56 Deeks, S. Hutter, G. New Engl. Gupta, R. Nature , — Li, J. The size of the expressed HIV reservoir predicts timing of viral rebound after treatment interruption. AIDS 30 , — Martin, A. Progress toward HIV eradication: case reports, current efforts, and the challenges associated with cure. Saez-Cirion, A.

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Switching Machines

PLoS Pathog. Siliciano, J. Xu, W. Advancements in developing strategies for sterilizing and functional HIV cures. Horwitz, J. HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. USA , — Sillman, B. Creation of a long-acting nanoformulated dolutegravir. Guo, D. Acquir Immune Defic. Singh, D. Development and characterization of a long-acting nanoformulated abacavir prodrug. Nanomedicine 11 , — Edagwa, B. Development of HIV reservoir targeted long acting nanoformulated antiretroviral therapies. Long-acting slow effective release antiretroviral therapy.

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Dash, P. Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIVinfected humanized mice. AIDS 26 , — Ottemann, B. Bioimaging predictors of rilpivirine biodistribution and antiretroviral activities. Biomaterials , — Hu, W. Kaminski, R.

Gene Ther. Negative feedback regulation of HIV-1 by gene editing strategy. White, M. Gene editing approaches against viral infections and strategy to prevent occurrence of viral escape. Yin, C. Hunsucker, S. Yuen, G. A review of the pharmacokinetics of abacavir. Singh, H. The promise of dolutegravir: a novel second generation integrase strand transfer inhibitor.

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Safety, efficacy, and pharmacokinetics of rilpivirine: systematic review with an emphasis on resource-limited settings. Zhou, T. Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials , 53—65 Gorantla, S.

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Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis. Loss of neuronal integrity during progressive HIV-1 infection of humanized mice. Boska, M. Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice. Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders?

NeuroImmune Pharmacol.

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