Synthetic Modulated Structures

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Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Nonribosomal peptide synthesis-principles and prospects. Hahn, M. Selective interaction between nonribosomal peptide synthetases is facilitated by short communication-mediating domains.

Natl Acad. USA , — Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides.

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Chiocchini, C. In vivo biocombinatorial synthesis of lipopeptides by COM domain-mediated reprogramming of the surfactin biosynthetic complex. Dehling, E. Mapping of the communication-mediating interface in nonribosomal peptide synthetases using a genetically encoded photocrosslinker supports an upside-down helix-hand motif. Broadhurst, R. The structure of docking domains in modular polyketide synthases.

Dorival, J. Characterization of intersubunit communication in the virginiamycin trans-acyl transferase polyketide synthase.

Supplementary files

Buchholz, T. Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. ACS Chem. Whicher, J. Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Richter, C. Multienzyme docking in hybrid megasynthetases. Dowling, D. Structural elements of an NRPS cyclization domain and its intermodule docking domain.

Cai, X. Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design.

Dds Chirp Generation

Montelione, G. Structure 21 , — Kronenwerth, M. Characterisation of taxlllaids A-G; natural products from Xenorhabdus indica. Weinig, S. Nishizawa, T. Characterization of the locus of genes encoding enzymes producing heptadepsipeptide micropeptin in the unicellular cyanobacterium Microcystis. Rounge, T. Comparison of cyanopeptolin genes in Planktothrix, Microcystis, and Anabaena Strains: evidence for independent evolution within each genus. Cheng, Y. Characterization of a gene cluster responsible for the biosynthesis of anticancer agent FK in Chromobacterium violaceum No.

Kitagaki, J. Cyclic depsipeptides as potential cancer therapeutics. Anti-Cancer Drugs 26 , — Kries, H. Biosynthetic engineering of nonribosomal peptide synthetases.

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NMR 4 , — Mulder, F. Altered flexibility in the substrate-binding site of related native and engineered high-alkaline Bacillus subtilisins.

Synthetic modulated structures edited by L. L. Chang and B. C. Giessen

Shen, Y. Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks. NMR 56 , — Herrmann, T.

Publication details

Automated structure determination from NMR spectra. Koradi, R. Point-centered domain decomposition for parallel molecular dynamics simulation. Ponder, J.

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Force fields for protein simulations. Protein Chem. Gottstein, D.

Simultaneous single-structure and bundle representation of protein NMR structures in torsion angle space. NMR 52 , — Bhattacharya, A. Evaluating protein structures determined by structural genomics consortia. Proteins 66 , — Dolinsky, T. Nucleic Acids Res. Seema V. Asymmetric synthesis of the constitutive Ccarboxylic acid of macroviracin A. Tetrahedron , 71 , Direct synthesis of macrodiolides via hafnium iv catalysis. Chemical Communications , 51 52 , Gregory Roos. Iron-Catalyzed Cross-Coupling Reactions.

go Chemistry - A European Journal , 19 11 , Angewandte Chemie International Edition , 51 48 , Angewandte Chemie , 48 , Laurean Ilies, Eiichi Nakamura.